
Research projects finished
Generation of a human iPSC
Generation of a human iPSC line from a patient with a mitochondrial encephalopathy due to mutations in the GFM1 gene
Duración
2 años
Presupuesto
202.125 €
Financiador
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Objetivo
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Resultados
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Human iPSC line GFM1SV.25 was generated from fibroblasts of a child with a severe mitochondrial encephalopathy associated with mutations in the GFM1 gene, encoding the mitochondrial translation elongation factor G1. Reprogramming factors OCT3/4, SOX2, CMYC and KLF4 were delivered using a non integrative methodology that involves the use of Sendai virus.
Execution: 100%